[ANSWER]NSC2500 Assignment 1 (Essay): Essential Hypertension and Calcium Channel Blockers

[ANSWER PREVIEW ON Essential Hypertension and Calcium Channel Blockers]

One of the possible pathophysiological mechanisms of essential hypertension involves salt intake. High intake of sodium chloride through diet can eventually lead to high blood pressure (Iqbal & Jamal, 2020). Sodium is significantly involved in blood volume regulation in that a high concentration of the element in the serum enhances fluid retention in the body, consequently raising blood volume and blood pressure (Oparil et al., 2018).

In people with normal blood pressure, high intake of sodium intake through diet activates compensatory mechanisms to normalise blood pressure. These mechanisms include a decrease in peripheral resistance and an increase in nitric oxide production in endothelial cells (Oparil et al., 2018). As nitric oxide helps in vasodilation, blood pressure increases when its effect is impaired. Additionally, dysfunction in the endothelium increases salt sensitivity, further raising blood pressure (Saxena et al., 2018). [Essential Hypertension]

The pathophysiology of essential hypertension may also involve the renin-angiotensin-aldosterone system (RAAS). Similar to sodium, the RAAS is involved in regulating blood volume and blood pressure, mostly within the renal system (Saxena et al., 2018). The RAAS also affects sodium retention, pressure natriuresis…[Buy Full Answer for Just USD 9: 1819 WORDS]

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Type: Essay

Word Count: 1819

Grade/Mark: 91 (Distinction)

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